Watch the full program here.

A recent breakthrough in our war against cancer is the development of therapies that harness our body’s immune system to seek out and destroy tumor cells. While such immunotherapies have significantly prolonged the life of some patients who had previously exhausted all treatment options, the majority of cancer patients still do not benefit from existing immunotherapies. Thus, there is an urgent need to devise new therapies that can benefit a larger population of cancer patients. A better understanding of the body’s immune system is also very important for the prevention and treatment of a growing list of autoimmune and inflammatory diseases, such as lupus, arthritis and neurodegenerative diseases. In these diseases, the immune system misfires and attacks our own tissues. Our immune system is also crucial for defending us from infections by a large variety of microbial pathogens, such as viruses, bacteria, and parasites.

Watch the Q&A portion here.

A recent breakthrough in our war against cancer is the development of therapies that harness our body’s immune system to seek out and destroy tumor cells. While such immunotherapies have significantly prolonged the life of some patients who had previously exhausted all treatment options, the majority of cancer patients still do not benefit from existing immunotherapies. Thus, there is an urgent need to devise new therapies that can benefit a larger population of cancer patients. A better understanding of the body’s immune system is also very important for the prevention and treatment of a growing list of autoimmune and inflammatory diseases, such as lupus, arthritis and neurodegenerative diseases. In these diseases, the immune system misfires and attacks our own tissues. Our immune system is also crucial for defending us from infections by a large variety of microbial pathogens, such as viruses, bacteria, and parasites. Key to our understanding of the immune system is how it detects microbial pathogens and cancer cells and how it avoids attacking our own tissues in normal situations. An important mechanism of this immune detection is the detection of DNA from microbial pathogens and cancer cells. Our lab discovered the DNA sensing enzyme cGAS and the pathway through which cGAS launches immune and autoimmune responses. Dr. Chen will discuss the current status of immunotherapies and describe efforts in harnessing the cGAS pathway to fight cancer and autoimmune diseases.

This program is generously supported by the Ann Lurie Trust.

As a part of our ongoing initiative to introduce students to STEM professionals from a wide variety of backgrounds, Horizon Therapeutics and The Chicago Council on Science and Technology visited Perspectives Math and Science Academy to talk to students about college and entering STEM fields. Watch the interview here and check for a new video each month.

Learn more about our partners

Horizon Therapeutics: https://www.horizonpharma.com

Perspectives Math and Science Academy: https://pcsedu.org/pcs-our-campuses/p…

Renowned Northwestern University molecular bio-scientist Neil Kelleher, who stands 5’0” tall in his socks, and his good friend Luka Mircovic, 6’11”, a former power forward for the 2012 Northwestern Wildcats, discuss the role of proteins in human health, disease, and how they can shape the diagnostics of the future. Professor Kelleher also reveals his massive worldwide effort to map one billion proteins throughout the human body ushering in a new era in human health. Once completed, the project is expected to give rise to new antibiotics and revolutionary technologies for detecting and treating cancer and other diseases.