The Malevolent, Misfolding Protein: Meet the Prion
By Zyara Morton, C2ST Intern, University of Illinois Urbana-Champaign
In 1980’s Britain, farmers across the country were reporting abnormal, concerning behaviors in their cattle. The cattle in question were exhibiting mood swings, lack of coordination, posture abnormalities, and sensory disturbances; such as sudden twitching. It was not long until this mysterious behavior was tied to a disease known as Bovine Spongiform Encephalopathy, more commonly known as, “Mad Cow” disease. The disease ravaged farms of cattle, and in 1996, the first human version of the disease, variant Creutzfeldt-Jakob Disease (cCJD) turned out to be fatal. This tragedy plunged the public into a spiral. What diseases can be spread from humans to animals? How can we protect against this? The following blog will dive into the culprit behind Mad Cow disease, and its perplexing nature, even in modern day — prions.